A company is designing a highly available, multi-region architecture for a web application. The application uses Amazon Route 53, Amazon CloudFront, Application Load Balancers (ALB), and Amazon EC2. The company wants to ensure that if the primary region goes down, traffic is automatically routed to the secondary region. Which combination of configurations should be used? (Select TWO)

Configure Route 53 with a Failover routing policy pointing to the CloudFront distributions.

Configure CloudFront Origin Groups with the primary ALB as the primary origin and the secondary ALB as the secondary origin.

Use AWS Global Accelerator to route traffic to the ALBs in both regions.

Configure the ALB in the primary region to forward traffic to the ALB in the secondary region.

Use Amazon S3 Cross-Region Replication to sync the EC2 instances.

Configure Route 53 health checks on the EC2 instances directly.