Medium1 markStructured
Cell BiologyHighermitosiscell cycleDNA replication

AQA GCSE · Question 05.5 · Cell Biology

One drug for treating malaria prevents mitosis occurring in the malarial protist. The drug stops the synthesis of new DNA bases in the cell. Suggest how the drug prevents mitosis occurring.

How to approach this question

Think about the cell cycle. What major event must happen before a cell can divide by mitosis? How would stopping the synthesis of DNA bases affect this event?

Full Answer

If new DNA bases cannot be synthesised, the cell cannot replicate its DNA/chromosomes. DNA replication is essential before mitosis can begin.
Mitosis is the process of cell division that produces two genetically identical daughter cells. Before mitosis can occur, the cell must go through a stage called interphase. A critical part of interphase is the synthesis (S) phase, where the cell replicates its entire set of DNA. This ensures that each daughter cell will receive a full copy of the genetic material. The drug stops the synthesis of new DNA bases, which are the building blocks of DNA. Without these building blocks, the cell cannot replicate its chromosomes. If DNA replication cannot be completed, the cell cycle arrests and cannot proceed to mitosis. Therefore, the protist cannot divide and multiply.

Common mistakes

✗ Saying it stops the cell growing - while true, the specific link is to DNA replication. ✗ Confusing mitosis with meiosis.

Practice the full AQA GCSE Biology Higher Tier Paper 1

52 questions · hints · full answers · grading

More questions from this exam